3PP4

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies

Summary for 3PP4

• Entry DOI: 10.2210/pdb3pp4/pdb
• Related: 3PP3
• Descriptor: GA101 Fab heavy chain, GA101 Fab light chain, B-lymphocyte antigen CD20, ... (5 entities in total)
• Functional Keywords: antibody fab fragment ig-domain, cd20, cyclic peptide, antibody antigen, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Membrane; Multi-pass membrane protein: P11836
• Total number of polymer chains: 3
• Total formula weight: 50822.21

Authors

Hopfner, K.-P.,Lammens, A. (deposition date: 2010-11-24, release date: 2011-04-13, Last modification date: 2023-09-06)

• Primary citation: Niederfellner, G.,Lammens, A.,Mundigl, O.,Georges, G.J.,Schaefer, W.,Schwaiger, M.,Franke, A.,Wiechmann, K.,Jenewein, S.,Slootstra, J.W.,Timmerman, P.,Brannstrom, A.,Lindstrom, F.,Mossner, E.,Umana, P.,Hopfner, K.P.,Klein, C.; Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.; Blood, 118:358-367, 2011; PubMed: 21444918; DOI: 10.1182/blood-2010-09-305847

Experimental method

X-RAY DIFFRACTION (1.6 Å)