3PP4

Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for the type I / type II distinction of anti- CD20 antibodies

3PP4 の概要

• エントリーDOI: 10.2210/pdb3pp4/pdb
• 関連するPDBエントリー: 3PP3
• 分子名称: GA101 Fab heavy chain, GA101 Fab light chain, B-lymphocyte antigen CD20, ... (5 entities in total)
• 機能のキーワード: antibody fab fragment ig-domain, cd20, cyclic peptide, antibody antigen, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Membrane; Multi-pass membrane protein: P11836
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50822.21

構造登録者

Hopfner, K.-P.,Lammens, A. (登録日: 2010-11-24, 公開日: 2011-04-13, 最終更新日: 2023-09-06)

• 主引用文献: Niederfellner, G.,Lammens, A.,Mundigl, O.,Georges, G.J.,Schaefer, W.,Schwaiger, M.,Franke, A.,Wiechmann, K.,Jenewein, S.,Slootstra, J.W.,Timmerman, P.,Brannstrom, A.,Lindstrom, F.,Mossner, E.,Umana, P.,Hopfner, K.P.,Klein, C.; Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.; Blood, 118:358-367, 2011; PubMed: 21444918; DOI: 10.1182/blood-2010-09-305847

実験手法

X-RAY DIFFRACTION (1.6 Å)