3PNH
Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in complex with 6-(((3R,4R)-4-(2-((2-FLUORO-2-(3-FLUOROPHENYL) ETHYL)AMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE
Summary for 3PNH
Entry DOI | 10.2210/pdb3pnh/pdb |
Related | 3PNE 3PNF 3PNG |
Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total) |
Functional Keywords | heme enzyme, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Cellular location | Cell membrane : P29473 |
Total number of polymer chains | 2 |
Total formula weight | 96848.14 |
Authors | Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2010-11-18, release date: 2011-10-05, Last modification date: 2024-02-21) |
Primary citation | Xue, F.,Kraus, J.M.,Labby, K.J.,Ji, H.,Mataka, J.,Xia, G.,Li, H.,Delker, S.L.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase. J.Med.Chem., 54:6399-6403, 2011 Cited by PubMed: 21809851DOI: 10.1021/jm200411j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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