Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HEM A 500 |
| Chain | Residue |
| A | TRP180 |
| A | 8CX800 |
| A | HOH1107 |
| A | HOH1207 |
| A | ARG185 |
| A | CYS186 |
| A | SER228 |
| A | PHE355 |
| A | SER356 |
| A | TRP358 |
| A | GLU363 |
| A | H4B600 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE H4B A 600 |
| Chain | Residue |
| A | SER104 |
| A | ARG367 |
| A | ALA448 |
| A | TRP449 |
| A | HEM500 |
| A | 8CX800 |
| A | GOL880 |
| A | HOH1072 |
| A | HOH1163 |
| B | TRP447 |
| B | PHE462 |
| B | HIS463 |
| B | GLN464 |
| B | GLU465 |
| B | HOH1090 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 860 |
| Chain | Residue |
| A | TRP358 |
| A | VAL420 |
| A | SER428 |
| A | HOH1175 |
| A | HOH1235 |
| A | HOH1316 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 880 |
| Chain | Residue |
| A | ARG367 |
| A | HIS373 |
| A | H4B600 |
| A | 8CX800 |
| A | HOH1084 |
| B | TRP76 |
| B | HOH1090 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CAD A 950 |
| Chain | Residue |
| A | THR85 |
| A | TRP324 |
| A | CYS384 |
| A | GLN437 |
| A | LYS438 |
| A | GLY441 |
| A | HOH1179 |
| A | HOH1303 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 8CX A 800 |
| Chain | Residue |
| A | VAL106 |
| A | ARG185 |
| A | GLN249 |
| A | VAL338 |
| A | PHE355 |
| A | SER356 |
| A | GLY357 |
| A | TRP358 |
| A | GLU363 |
| A | TRP449 |
| A | TYR477 |
| A | HEM500 |
| A | H4B600 |
| A | GOL880 |
| A | HOH1204 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 900 |
| Chain | Residue |
| A | CYS96 |
| A | CYS101 |
| B | CYS96 |
| B | CYS101 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM B 500 |
| Chain | Residue |
| B | TRP180 |
| B | ARG185 |
| B | CYS186 |
| B | SER228 |
| B | PHE355 |
| B | SER356 |
| B | TRP358 |
| B | GLU363 |
| B | PHE475 |
| B | H4B600 |
| B | 8CX800 |
| B | HOH1030 |
| B | HOH1221 |
| B | HOH1314 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE H4B B 600 |
| Chain | Residue |
| A | TRP447 |
| A | PHE462 |
| A | HIS463 |
| A | GLU465 |
| B | SER104 |
| B | ARG367 |
| B | ALA448 |
| B | TRP449 |
| B | HEM500 |
| B | 8CX800 |
| B | GOL880 |
| B | HOH1038 |
| B | HOH1049 |
| B | HOH1133 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 860 |
| Chain | Residue |
| B | HOH1115 |
| B | HOH1119 |
| B | HOH1303 |
| B | GLY188 |
| B | TRP358 |
| B | VAL420 |
| B | SER428 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 880 |
| Chain | Residue |
| B | VAL106 |
| B | ARG367 |
| B | HIS373 |
| B | H4B600 |
| B | HOH1049 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 8CX B 800 |
| Chain | Residue |
| A | TRP76 |
| B | VAL106 |
| B | LEU107 |
| B | ARG185 |
| B | GLN249 |
| B | PRO336 |
| B | VAL338 |
| B | PHE355 |
| B | GLY357 |
| B | TRP358 |
| B | GLU363 |
| B | TRP449 |
| B | TYR477 |
| B | HEM500 |
| B | H4B600 |
| B | HOH1259 |
| B | HOH1314 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CAD B 950 |
| Chain | Residue |
| B | TYR83 |
| B | TRP324 |
| B | CYS384 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG185-TRP192 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P35228","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29474","evidenceCode":"ECO:0000250"}]} |
