3PN1

Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo

3PN1 の概要

• エントリーDOI: 10.2210/pdb3pn1/pdb
• 分子名称: DNA ligase, 2-(butylsulfanyl)adenosine, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: atp grasp fold, ligase, dna, bacteria, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Haemophilus influenzae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36411.29

構造登録者

Mills, S.,Eakin, A.,Buurman, E.,Newman, J.,Gao, N.,Huynh, H.,Johnson, K.,Lahiri, S.,Shapiro, A.,Walkup, G.,Wei, Y.,Stokes, S. (登録日: 2010-11-18, 公開日: 2011-01-12, 最終更新日: 2024-02-21)

• 主引用文献: Mills, S.D.,Eakin, A.E.,Buurman, E.T.,Newman, J.V.,Gao, N.,Huynh, H.,Johnson, K.D.,Lahiri, S.,Shapiro, A.B.,Walkup, G.K.,Yang, W.,Stokes, S.S.; Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo.; Antimicrob.Agents Chemother., 55:1088-1096, 2011; PubMed: 21189350; DOI: 10.1128/AAC.01181-10

実験手法

X-RAY DIFFRACTION (2 Å)