3PLZ
Human LRH1 LBD bound to GR470
Summary for 3PLZ
Entry DOI | 10.2210/pdb3plz/pdb |
Related | 1YOK |
Descriptor | FTZ-F1 related protein, Nuclear receptor coactivator 2, (3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-2,3,6,6a-tetrahydropentalen-3a(1H)-amine, ... (5 entities in total) |
Functional Keywords | alpha helical sandwhich, nuclear receptor, family five, transcription factor, co-activator, transcription-receptor-agonist complex, transcription/receptor/agonist |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : Q9UEC0 Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 64028.31 |
Authors | Williams, S.P.,Xu, R.,Zuercher, W.J. (deposition date: 2010-11-15, release date: 2011-03-30, Last modification date: 2024-02-21) |
Primary citation | Whitby, R.J.,Stec, J.,Blind, R.D.,Dixon, S.,Leesnitzer, L.M.,Orband-Miller, L.A.,Williams, S.P.,Willson, T.M.,Xu, R.,Zuercher, W.J.,Cai, F.,Ingraham, H.A. Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2). J.Med.Chem., 54:2266-2281, 2011 Cited by PubMed: 21391689DOI: 10.1021/jm1014296 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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