3PLQ

Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS

3PLQ の概要

• エントリーDOI: 10.2210/pdb3plq/pdb
• 分子名称: cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, ... (4 entities in total)
• 機能のキーワード: pka, transferase inhibitor
• 由来する生物種: Bos taurus (bovine)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17829.14

構造登録者

Swaminathan, K. (登録日: 2010-11-15, 公開日: 2010-12-01, 最終更新日: 2023-11-01)

• 主引用文献: Swaminathan, K.; Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design; To be Published,

実験手法

X-RAY DIFFRACTION (2.3 Å)