3PK1
Crystal structure of Mcl-1 in complex with the BaxBH3 domain
Summary for 3PK1
Entry DOI | 10.2210/pdb3pk1/pdb |
Related | 3PL7 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Apoptosis regulator BAX, CADMIUM ION, ... (4 entities in total) |
Functional Keywords | bcl-2 family fold, regulation of apoptosis, bax, mitochondria, apoptosis-apoptosis regulator complex, apoptosis/apoptosis regulator |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q07820 Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential): Q07812 |
Total number of polymer chains | 4 |
Total formula weight | 52254.30 |
Authors | Czabotar, P.E.,Colman, P.M. (deposition date: 2010-11-11, release date: 2010-12-29, Last modification date: 2023-11-01) |
Primary citation | Czabotar, P.E.,Lee, E.F.,Thompson, G.V.,Wardak, A.Z.,Fairlie, W.D.,Colman, P.M. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis J.Biol.Chem., 286:7123-7131, 2011 Cited by PubMed: 21199865DOI: 10.1074/jbc.M110.161281 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.486 Å) |
Structure validation
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