3PJC
Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family
Summary for 3PJC
Entry DOI | 10.2210/pdb3pjc/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione (3 entities in total) |
Functional Keywords | small molecule inhibitor, atp site kinase inhibitor, atp-binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): P52333 |
Total number of polymer chains | 1 |
Total formula weight | 36152.14 |
Authors | Tavares, G.A.,Thoma, G.,Zerwes, H.-G.,Kroemer, M. (deposition date: 2010-11-09, release date: 2010-12-29, Last modification date: 2024-02-21) |
Primary citation | Thoma, G.,Nuninger, F.,Falchetto, R.,Hermes, E.,Tavares, G.A.,Vangrevelinghe, E.,Zerwes, H.G. Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family. J.Med.Chem., 54:284-288, 2011 Cited by PubMed: 21155605DOI: 10.1021/jm101157q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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