3PJC
Crystal structure of JAK3 complexed with a potent ATP site inhibitor showing high selectivity within the Janus kinase family
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK3 | polymer | 315 | 35696.8 | 1 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK |
| 2 | B (A) | 3-(1H-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrrole-2,5-dione | non-polymer | 455.4 | 1 | Chemie (PJC) | |||
| 3 | C (A) | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 812 - 1124 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Gly 810 | - | expression tag |
| Pro 811 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35696.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 455.4 | |
| All* | Total formula weight | 36152.1 |
