3PHE

HCV NS5B with a bound quinolone inhibitor

Summary for 3PHE

Entry DOI	10.2210/pdb3phe/pdb
Descriptor	HCV encoded nonstructural 5B protein, 4-chlorobenzyl 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(methylsulfonyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate (3 entities in total)
Functional Keywords	transferase, polymerase, rna, mitochondrial membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Hepatitis C virus
Total number of polymer chains	4
Total formula weight	258806.20
Authors	Somoza, J.R.,To, N.,Lehoux, I. (deposition date: 2010-11-03, release date: 2010-11-17, Last modification date: 2024-02-21)
Primary citation	Kumar, D.V.,Rai, R.,Brameld, K.A.,Somoza, J.R.,Rajagopalan, R.,Janc, J.W.,Xia, Y.M.,Ton, T.L.,Shaghafi, M.B.,Hu, H.,Lehoux, I.,To, N.,Young, W.B.,Green, M.J. Quinolones as HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 21:82-87, 2011 Cited by PubMed: 21145235 DOI: 10.1016/j.bmcl.2010.11.068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation