3PE6

Crystal Structure of a soluble form of human MGLL in complex with an inhibitor

3PE6 の概要

• エントリーDOI: 10.2210/pdb3pe6/pdb
• 関連するPDBエントリー: 3HJU 3JW8 3JWE
• 分子名称: Monoglyceride lipase, (2-cyclohexyl-1,3-benzoxazol-6-yl){3-[4-(pyrimidin-2-yl)piperazin-1-yl]azetidin-1-yl}methanone (3 entities in total)
• 機能のキーワード: alpha-beta hydrolase fold, lipase, 2-arachidonyl-glycerol, membrane associated, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33637.67

構造登録者

Schubert, C.,Schalk-Hih, C. (登録日: 2010-10-25, 公開日: 2011-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Schalk-Hihi, C.,Schubert, C.,Alexander, R.,Bayoumy, S.,Clemente, J.C.,Deckman, I.,DesJarlais, R.L.,Dzordzorme, K.C.,Flores, C.M.,Grasberger, B.,Kranz, J.K.,Lewandowski, F.,Liu, L.,Ma, H.,Maguire, D.,Macielag, M.J.,McDonnell, M.E.,Mezzasalma Haarlander, T.,Miller, R.,Milligan, C.,Reynolds, C.,Kuo, L.C.; Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution.; Protein Sci., 20:670-683, 2011; PubMed: 21308848; DOI: 10.1002/pro.596

実験手法

X-RAY DIFFRACTION (1.35 Å)