3PE6
Crystal Structure of a soluble form of human MGLL in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Monoglyceride lipase | polymer | 303 | 33191.1 | 1 | UniProt (Q6IBG9) Pfam (PF12146) UniProt (by SIFTS) (Q99685) In PDB | Homo sapiens (human) | MGLL protein, isoform CRA_b, cDNA, FLJ96595, Homo sapiens monoglyceride lipase (MGLL), mRNA |
| 2 | A | (2-cyclohexyl-1,3-benzoxazol-6-yl){3-[4-(pyrimidin-2-yl)piperazin-1-yl]azetidin-1-yl}methanone | non-polymer | 446.5 | 1 | Chemie (ZYH) | |||
| 3 | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A: 1 - 303 (UniProt: Q6IBG9)
| PDB | External Database | Details |
|---|---|---|
| Ala 36 | Lys 46 | engineered mutation |
| Ser 169 | Leu 179 | engineered mutation |
| Ser 176 | Leu 186 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33191.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 446.5 | |
| All* | Total formula weight | 33637.7 |
