3P8Z
Dengue Methyltransferase bound to a SAM-based inhibitor
Summary for 3P8Z
Entry DOI | 10.2210/pdb3p8z/pdb |
Related | 3P97 |
Descriptor | Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
Functional Keywords | methyltransferase, rna, er, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Dengue virus 3 |
Cellular location | Envelope protein E: Virion membrane; Multi- pass membrane protein: C1KBQ3 |
Total number of polymer chains | 2 |
Total formula weight | 61032.56 |
Authors | Noble, C.G.,Yap, L.J.,Lescar, J. (deposition date: 2010-10-15, release date: 2010-12-08, Last modification date: 2023-11-01) |
Primary citation | Lim, S.P.,Sonntag, L.S.,Noble, C.,Nilar, S.H.,Ng, R.H.,Zou, G.,Monaghan, P.,Chung, K.Y.,Dong, H.,Liu, B.,Bodenreider, C.,Lee, G.,Ding, M.,Chan, W.L.,Wang, G.,Jian, Y.L.,Chao, A.T.,Lescar, J.,Yin, Z.,Vedananda, T.R.,Keller, T.H.,Shi, P.Y. Small molecule inhibitors that selectively block dengue virus methyltransferase J.Biol.Chem., 286:6233-6240, 2011 Cited by PubMed: 21147775DOI: 10.1074/jbc.M110.179184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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