3P8Z

Dengue Methyltransferase bound to a SAM-based inhibitor

3P8Z の概要

• エントリーDOI: 10.2210/pdb3p8z/pdb
• 関連するPDBエントリー: 3P97
• 分子名称: Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: methyltransferase, rna, er, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Dengue virus 3
• 細胞内の位置: Envelope protein E: Virion membrane; Multi- pass membrane protein: C1KBQ3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61032.56

構造登録者

Noble, C.G.,Yap, L.J.,Lescar, J. (登録日: 2010-10-15, 公開日: 2010-12-08, 最終更新日: 2023-11-01)

• 主引用文献: Lim, S.P.,Sonntag, L.S.,Noble, C.,Nilar, S.H.,Ng, R.H.,Zou, G.,Monaghan, P.,Chung, K.Y.,Dong, H.,Liu, B.,Bodenreider, C.,Lee, G.,Ding, M.,Chan, W.L.,Wang, G.,Jian, Y.L.,Chao, A.T.,Lescar, J.,Yin, Z.,Vedananda, T.R.,Keller, T.H.,Shi, P.Y.; Small molecule inhibitors that selectively block dengue virus methyltransferase; J.Biol.Chem., 286:6233-6240, 2011; PubMed: 21147775; DOI: 10.1074/jbc.M110.179184

実験手法

X-RAY DIFFRACTION (1.7 Å)