3P7G
Structure of the human Langerin carbohydrate recognition domain in complex with mannose
Replaces: 3BC7Summary for 3P7G
Entry DOI | 10.2210/pdb3p7g/pdb |
Related | 3P7F 3P7H |
Descriptor | C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-mannopyranose, ... (4 entities in total) |
Functional Keywords | c-type lectin, membrane protein, glycoprotein, langerin, dc-sign, carbohydrate binding protein, calcium binding, sugar binding, immune system, langerhans cells, cd207 |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type II membrane protein : Q9UJ71 |
Total number of polymer chains | 4 |
Total formula weight | 68291.47 |
Authors | Skerra, A.,Schiefner, A. (deposition date: 2010-10-12, release date: 2010-11-03, Last modification date: 2020-07-29) |
Primary citation | Chatwell, L.,Holla, A.,Kaufer, B.B.,Skerra, A. The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site. Mol.Immunol., 45:1981-1994, 2008 Cited by PubMed: 18061677DOI: 10.1016/j.molimm.2007.10.030 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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