3P7B

p38 inhibitor-bound

Summary for 3P7B

Entry DOI	10.2210/pdb3p7b/pdb
Related	3P5K 3P78 3P79 3P7A 3P7C
Descriptor	Mitogen-activated protein kinase 14, 1-{5-tert-butyl-3-[(5-oxo-1,4-diazepan-1-yl)carbonyl]thiophen-2-yl}-3-naphthalen-1-ylurea, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	42856.92
Authors	Moffett, K.K.,Namboodiri, H. (deposition date: 2010-10-12, release date: 2011-10-12, Last modification date: 2024-02-21)
Primary citation	Moffett, K.,Konteatis, Z.,Nguyen, D.,Shetty, R.,Ludington, J.,Fujimoto, T.,Lee, K.J.,Chai, X.,Namboodiri, H.,Karpusas, M.,Dorsey, B.,Guarnieri, F.,Bukhtiyarova, M.,Springman, E.,Michelotti, E. Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Bioorg.Med.Chem.Lett., 21:7155-7165, 2011 Cited by PubMed: 22014550 DOI: 10.1016/j.bmcl.2011.09.078 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation