3P60
Crystal structure of the mutant T159V of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Summary for 3P60
Entry DOI | 10.2210/pdb3p60/pdb |
Related | 3LTP 3P5Y 3P5Z 3P61 |
Descriptor | Orotidine 5'-monophosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE (3 entities in total) |
Functional Keywords | tim barrel, orotidine 5'-monophosphate decarboxylase, inhibitor bmp, lyase |
Biological source | Methanobacterium thermoautotrophicum |
Total number of polymer chains | 2 |
Total formula weight | 50445.81 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-10-11, release date: 2011-09-21, Last modification date: 2023-09-06) |
Primary citation | Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629DOI: 10.1021/bi301188k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report