3P5R

Crystal Structure of Taxadiene Synthase from Pacific Yew (Taxus brevifolia) in complex with Mg2+ and 2-fluorogeranylgeranyl diphosphate

Summary for 3P5R

Entry DOI	10.2210/pdb3p5r/pdb
Related	3P5P
Descriptor	Taxadiene synthase, MAGNESIUM ION, (2Z,6E,10E)-2-fluoro-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate, ... (4 entities in total)
Functional Keywords	class i and ii terpene cyclase fold, diterpene cyclase, ddxxd motif, nse/dte motif, 2-fluoro-geranylgeranyl diphosphate, biosynthesis of paclitaxel, lyase
Biological source	Taxus brevifolia (Pacific yew)
Total number of polymer chains	2
Total formula weight	176685.95
Authors	Koksal, M.,Christianson, D.W. (deposition date: 2010-10-10, release date: 2010-12-29, Last modification date: 2023-09-06)
Primary citation	Koksal, M.,Jin, Y.,Coates, R.M.,Croteau, R.,Christianson, D.W. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature, 469:116-120, 2011 Cited by PubMed: 21160477 DOI: 10.1038/nature09628 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.247 Å)

Structure validation