3P5J

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Summary for 3P5J

Related3P56
DescriptorRibonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C (3 entities in total)
Functional Keywordsrnase h2 fold, triple beta-barrel, nuclease that cleaves rna/dna hybrids, proliferating cell nuclear antigen (pcna) and rna/dna hybrids, nucleus, hydrolase-replication complex, hydrolase/replication
Biological sourceMus musculus (mouse)
Cellular locationNucleus (By similarity) Q9CWY8 Q80ZV0 Q9CQ18
Total number of polymer chains3
Total molecular weight88889.91
Authors
Bubeck, D.,Graham, S.C.,Jones, E.Y. (deposition date: 2010-10-08, release date: 2010-11-17, Last modification date: 2011-10-12)
Primary citation
Reijns, M.A.,Bubeck, D.,Gibson, L.C.,Graham, S.C.,Baillie, G.S.,Jones, E.Y.,Jackson, A.P.
The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease.
J.Biol.Chem., 286:10530-10539, 2011
PubMed: 21177854 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.177394
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28541.3%8.0%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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