3P1D
Crystal structure of the bromodomain of human CREBBP in complex with N-Methyl-2-pyrrolidone (NMP)
Summary for 3P1D
Entry DOI | 10.2210/pdb3p1d/pdb |
Related | 3P1C 3P1E 3P1F |
Descriptor | CREB-binding protein, THIOCYANATE ION, 1-methylpyrrolidin-2-one, ... (5 entities in total) |
Functional Keywords | structural genomics consortium, sgc, cbp, crebbp, creb binding protein isoform a, kat3a, rsts, rst, bromodomain, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 2 |
Total formula weight | 28742.14 |
Authors | Filippakopoulos, P.,Picaud, S.,Feletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-09-30, release date: 2010-11-24, Last modification date: 2023-09-06) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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