3P0N

Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor

3P0N の概要

• エントリーDOI: 10.2210/pdb3p0n/pdb
• 関連するPDBエントリー: 3KR7 3P0P 3P0Q
• 分子名称: Tankyrase-2, ZINC ION, 7-bromopyrrolo[1,2-a]quinoxalin-4(5H)-one, ... (6 entities in total)
• 機能のキーワード: protein-ligand complex, structural genomics, structural genomics consortium, sgc, diphtheria toxin like fold, transferase, nad+, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q9H2K2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55828.93

構造登録者

Karlberg, T.,Siponen, M.I.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Schutz, P.,Sehic, A.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Wahlberg, E.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (登録日: 2010-09-29, 公開日: 2010-10-20, 最終更新日: 2023-11-01)

• 主引用文献: Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J.; Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors; Nat.Biotechnol., 30:283-288, 2012; PubMed: 22343925; DOI: 10.1038/nbt.2121

実験手法

X-RAY DIFFRACTION (1.9 Å)