3P0L

Human steroidogenic acute regulatory protein

3P0L の概要

• エントリーDOI: 10.2210/pdb3p0l/pdb
• 分子名称: Steroidogenic acute regulatory protein, mitochondrial (1 entity in total)
• 機能のキーワード: structural genomics consortium, sgc, start domain, cholesterol transport, cholesterol, mitochondria, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion: P49675
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98821.57

構造登録者

Lehtio, L.,Siponen, M.,Arrowsmith, C.H.,Berglund, H.,Busam, R.D.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Herman, M.D.,Johansson, A.,Johansson, I.,Kallas, A.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Schuler, H.,Structural Genomics Consortium (SGC) (登録日: 2010-09-29, 公開日: 2010-11-24, 最終更新日: 2023-09-06)

主引用文献

Thorsell, A.G.,Lee, W.H.,Persson, C.,Siponen, M.I.,Nilsson, M.,Busam, R.D.,Kotenyova, T.,Schuler, H.,Lehtio, L.
Comparative structural analysis of lipid binding START domains.
Plos One, 6:e19521-e19521, 2011

PubMed Abstract: Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.

PubMed: 21738568
DOI: 10.1371/journal.pone.0019521

実験手法

X-RAY DIFFRACTION (3.4 Å)