3OZJ

Crystal structure of human retinoic X receptor alpha complexed with bigelovin and coactivator SRC-1

3OZJ の概要

• エントリーDOI: 10.2210/pdb3ozj/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, SRC-1, peptide of Nuclear receptor coactivator 2, (3aR,4S,4aR,7aR,8R,9aS)-4a,8-dimethyl-3-methylidene-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl acetate, ... (4 entities in total)
• 機能のキーワード: nuclear receptor ligand-binding domain, ligand-binding and transactivation, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P19793 Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56755.81

構造登録者

Zhang, H.,Li, L.,Chen, L.,Hu, L.,Shen, X. (登録日: 2010-09-25, 公開日: 2011-02-02, 最終更新日: 2023-11-01)

• 主引用文献: Zhang, H.,Li, L.,Chen, L.,Hu, L.,Jiang, H.,Shen, X.; Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode; J.Mol.Biol., 407:13-20, 2011; PubMed: 21262235; DOI: 10.1016/j.jmb.2011.01.032

実験手法

X-RAY DIFFRACTION (2.1 Å)