3OZF

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine

Summary for 3OZF

• Entry DOI: 10.2210/pdb3ozf/pdb
• Related: 3OZG
• Descriptor: Hypoxanthine-guanine-xanthine phosphoribosyltransferase, HYPOXANTHINE, PYROPHOSPHATE 2-, ... (6 entities in total)
• Functional Keywords: hypoxanthine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Plasmodium falciparum FCR-3/Gambia
• Cellular location: Cytoplasm: P20035
• Total number of polymer chains: 4
• Total formula weight: 115416.77

Authors

Ho, M.,Hazleton, K.Z.,Almo, S.C.,Schramm, V.L. (deposition date: 2010-09-24, release date: 2011-09-28, Last modification date: 2024-02-21)

• Primary citation: Hazleton, K.Z.,Ho, M.C.,Cassera, M.B.,Clinch, K.,Crump, D.R.,Rosario, I.,Merino, E.F.,Almo, S.C.,Tyler, P.C.,Schramm, V.L.; Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase.; Chem.Biol., 19:721-730, 2012; PubMed: 22726686; DOI: 10.1016/j.chembiol.2012.04.012

Experimental method

X-RAY DIFFRACTION (1.944 Å)