3OZ4

R-Methyl Carbocyclic LNA

Summary for 3OZ4

• Entry DOI: 10.2210/pdb3oz4/pdb
• Related: 3OZ3 3OZ5
• Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(URX)P*AP*CP*GP*C)-3') (2 entities in total)
• Functional Keywords: a-form dna, r-methyl carbocyclic lna, r-me-c-lna, antisense oligonucleotides, dna
• Total number of polymer chains: 2
• Total formula weight: 6142.09

Authors

Seth, P.R.,Allerson, C.A.,Berdeja, A.,Siwkowski, A.,Pallan, P.S.,Gaus, H.,Prakash, T.P.,Watt, A.T.,Egli, M.,Swayze, E.E. (deposition date: 2010-09-24, release date: 2010-11-24, Last modification date: 2023-09-06)

• Primary citation: Seth, P.P.,Allerson, C.R.,Berdeja, A.,Siwkowski, A.,Pallan, P.S.,Gaus, H.,Prakash, T.P.,Watt, A.T.,Egli, M.,Swayze, E.E.; An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.; J.Am.Chem.Soc., 132:14942-14950, 2010; PubMed: 20886816; DOI: 10.1021/ja105875e

Experimental method

X-RAY DIFFRACTION (1.59 Å)