3OY1

Highly Selective c-Jun N-Terminal Kinase (JNK) 2 and 3 Inhibitors with In Vitro CNS-like Pharmacokinetic Properties

3OY1 の概要

• エントリーDOI: 10.2210/pdb3oy1/pdb
• 分子名称: Mitogen-activated protein kinase 10, 5-[2-(cyclohexylamino)pyridin-4-yl]-4-naphthalen-2-yl-2-(tetrahydro-2H-pyran-4-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one (3 entities in total)
• 機能のキーワード: kinase inhibitor, cns, selectivity, transferase, transherase-transferase inhibitor complex, transherase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42268.94

構造登録者

Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.,Neitz, J.,Hom, R.K.,Galemmo Jr., R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.,Pan, H.,Yao, N. (登録日: 2010-09-22, 公開日: 2011-08-17, 最終更新日: 2024-02-21)

• 主引用文献: Probst, G.D.,Bowers, S.,Sealy, J.M.,Truong, A.P.,Hom, R.K.,Galemmo, R.A.,Konradi, A.W.,Sham, H.L.,Quincy, D.A.,Pan, H.,Yao, N.,Lin, M.,Toth, G.,Artis, D.R.,Zmolek, W.,Wong, K.,Qin, A.,Lorentzen, C.,Nakamura, D.F.,Quinn, K.P.,Sauer, J.M.,Powell, K.,Ruslim, L.,Wright, S.,Chereau, D.,Ren, Z.,Anderson, J.P.,Bard, F.,Yednock, T.A.,Griswold-Prenner, I.; Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.; Bioorg.Med.Chem.Lett., 21:315-319, 2011; PubMed: 21112785; DOI: 10.1016/j.bmcl.2010.11.010

実験手法

X-RAY DIFFRACTION (1.7 Å)