3OWN

Potent macrocyclic renin inhibitors

Summary for 3OWN

Entry DOI	10.2210/pdb3own/pdb
Descriptor	Renin, ACETATE ION, SODIUM ION, ... (6 entities in total)
Functional Keywords	renin, protease, aspartyl protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	76419.15
Authors	Borkakoti, N.,Derbyshire, D. (deposition date: 2010-09-20, release date: 2010-12-15, Last modification date: 2011-07-13)
Primary citation	Sund, C.,Belda, O.,Wiktelius, D.,Sahlberg, C.,Vrang, L.,Sedig, S.,Hamelink, E.,Henderson, I.,Agback, T.,Jansson, K.,Borkakoti, N.,Derbyshire, D.,Eneroth, A.,Samuelsson, B. Design and synthesis of potent macrocyclic renin inhibitors. Bioorg.Med.Chem.Lett., 21:358-362, 2011 Cited by PubMed: 21112780 DOI: 10.1016/j.bmcl.2010.10.140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation