3OVZ
Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead
Summary for 3OVZ
Entry DOI | 10.2210/pdb3ovz/pdb |
Related | 3OVX |
Descriptor | Cathepsin K, N-[(1S)-3-amino-1-ethyl-2,3-dioxopropyl]-2-chloro-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | cathepsin k, hydrolase, covalent inhibitor, ketoamide warhead, ligand forms covalent bond to cys25, lysosomes, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 23991.22 |
Authors | Fradera, X.,van Zeeland, M.,Uitdehaag, J.C.M. (deposition date: 2010-09-17, release date: 2010-12-22, Last modification date: 2024-04-03) |
Primary citation | Cai, J.,Robinson, J.,Belshaw, S.,Everett, K.,Fradera, X.,van Zeeland, M.,van Berkom, L.,van Rijnsbergen, P.,Popplestone, L.,Baugh, M.,Dempster, M.,Bruin, J.,Hamilton, W.,Kinghorn, E.,Westwood, P.,Kerr, J.,Rankovic, Z.,Arbuckle, W.,Bennett, D.J.,Jones, P.S.,Long, C.,Martin, I.,Uitdehaag, J.C.,Meulemans, T. Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Bioorg.Med.Chem.Lett., 20:6890-6894, 2010 Cited by PubMed: 21030256DOI: 10.1016/j.bmcl.2010.10.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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