3OTX

Crystal Structure of Trypanosoma brucei rhodesiense Adenosine Kinase Complexed with Inhibitor AP5A

3OTX の概要

• エントリーDOI: 10.2210/pdb3otx/pdb
• 関連するPDBエントリー: 2XTB
• 分子名称: Adenosine kinase, putative, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: adenosine kinase, ap5a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Trypanosoma brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78141.67

構造登録者

Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R. (登録日: 2010-09-14, 公開日: 2011-06-29, 最終更新日: 2024-10-30)

主引用文献

Kuettel, S.,Greenwald, J.,Kostrewa, D.,Ahmed, S.,Scapozza, L.,Perozzo, R.
Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation
Plos Negl Trop Dis, 5:e1164-e1164, 2011

PubMed Abstract: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of the key enzymes is adenosine kinase which catalyzes the phosphorylation of ingested adenosine to form adenosine monophosphate (AMP) utilizing adenosine triphosphate (ATP) as the preferred phosphoryl donor.

PubMed: 21629723
DOI: 10.1371/journal.pntd.0001164

実験手法

X-RAY DIFFRACTION (1.55 Å)