3OT3
X-ray crystal structure of compound 22k bound to human Chk1 kinase domain
Summary for 3OT3
Entry DOI | 10.2210/pdb3ot3/pdb |
Related | 3OT8 |
Descriptor | Serine/threonine-protein kinase Chk1, 5-[(1R,3S)-3-aminocyclohexyl]-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine (3 entities in total) |
Functional Keywords | kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31845.51 |
Authors | Fischmann, T.O. (deposition date: 2010-09-10, release date: 2010-11-10, Last modification date: 2023-09-06) |
Primary citation | Labroli, M.,Paruch, K.,Dwyer, M.P.,Alvarez, C.,Keertikar, K.,Poker, C.,Rossman, R.,Duca, J.S.,Fischmann, T.O.,Madison, V.,Parry, D.,Davis, N.,Seghezzi, W.,Wiswell, D.,Guzi, T.J. Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2. Bioorg.Med.Chem.Lett., 21:471-474, 2011 Cited by PubMed: 21094607DOI: 10.1016/j.bmcl.2010.10.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.44 Å) |
Structure validation
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