3OSW

Crystal structure of PPARgamma ligand binding domain in complex with tetrabromo-bisphenol A (TBBPA)

3OSW の概要

• エントリーDOI: 10.2210/pdb3osw/pdb
• 関連するPDBエントリー: 3OSI
• 分子名称: Peroxisome proliferator-activated receptor gamma, 4,4'-propane-2,2-diylbis(2,6-dibromophenol), S-1,2-PROPANEDIOL, ... (4 entities in total)
• 機能のキーワード: transcription, ligand binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65539.11

構造登録者

le Maire, A.,Bourguet, W. (登録日: 2010-09-10, 公開日: 2011-05-25, 最終更新日: 2024-02-21)

主引用文献

Riu, A.,Grimaldi, M.,le Maire, A.,Bey, G.,Phillips, K.,Boulahtouf, A.,Perdu, E.,Zalko, D.,Bourguet, W.,Balaguer, P.
Peroxisome proliferator-activated receptor Gamma is a target for halogenated analogs of bisphenol A.
Environ.Health Perspect., 119:1227-1232, 2011

PubMed Abstract: The occurrence of halogenated analogs of the xenoestrogen bisphenol A (BPA) has been recently demonstrated both in environmental and human samples. These analogs include brominated [e.g., tetrabromobisphenol A (TBBPA)] and chlorinated [e.g., tetrachlorobisphenol A (TCBPA)] bisphenols, which are both flame retardants. Because of their structural homology with BPA, such chemicals are candidate endocrine disruptors. However, their possible target(s) within the nuclear hormone receptor superfamily has remained unknown.

PubMed: 21561829
DOI: 10.1289/ehp.1003328

実験手法

X-RAY DIFFRACTION (2.55 Å)