3OSK

Crystal structure of human CTLA-4 apo homodimer

Summary for 3OSK

Entry DOI	10.2210/pdb3osk/pdb
Descriptor	Cytotoxic T-lymphocyte protein 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
Functional Keywords	beta sandwich, homodimer, immunoglobulin superfamily (beta sandwich) fold, receptor, signalling, b7-1(cd80), b7-2(cd86), membrane, immune system
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P16410
Total number of polymer chains	2
Total formula weight	28580.48
Authors	Yu, C.,Sonnen, A.F.-P.,Ikemizu, S.,Stuart, D.I.,Gilbert, R.J.C.,Davis, S.J. (deposition date: 2010-09-09, release date: 2010-12-08, Last modification date: 2023-11-01)
Primary citation	Yu, C.,Sonnen, A.F.-P.,George, R.,Dessailly, B.H.,Stagg, L.J.,Evans, E.J.,Orengo, C.A.,Stuart, D.I.,Ladbury, J.E.,Ikemizu, S.,Gilbert, R.J.C.,Davis, S.J. Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering J.Biol.Chem., 286:6685-6696, 2011 Cited by PubMed: 21156796 DOI: 10.1074/jbc.M110.182394 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation