3OSK

Crystal structure of human CTLA-4 apo homodimer

3OSK の概要

• エントリーDOI: 10.2210/pdb3osk/pdb
• 分子名称: Cytotoxic T-lymphocyte protein 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: beta sandwich, homodimer, immunoglobulin superfamily (beta sandwich) fold, receptor, signalling, b7-1(cd80), b7-2(cd86), membrane, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P16410
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28580.48

構造登録者

Yu, C.,Sonnen, A.F.-P.,Ikemizu, S.,Stuart, D.I.,Gilbert, R.J.C.,Davis, S.J. (登録日: 2010-09-09, 公開日: 2010-12-08, 最終更新日: 2023-11-01)

• 主引用文献: Yu, C.,Sonnen, A.F.-P.,George, R.,Dessailly, B.H.,Stagg, L.J.,Evans, E.J.,Orengo, C.A.,Stuart, D.I.,Ladbury, J.E.,Ikemizu, S.,Gilbert, R.J.C.,Davis, S.J.; Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering; J.Biol.Chem., 286:6685-6696, 2011; PubMed: 21156796; DOI: 10.1074/jbc.M110.182394

実験手法

X-RAY DIFFRACTION (1.8 Å)