3OQ5

Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1

Summary for 3OQ5

• Entry DOI: 10.2210/pdb3oq5/pdb
• Descriptor: Lethal(3)malignant brain tumor-like protein, Cellular tumor antigen p53 (3 entities in total)
• Functional Keywords: l(3)mbt-like protein, protein lysine methyltransferase; malignant brain tumor, chromatin regulator, dna-binding, metal-binding, nucleus, repressor, transcription regulation, zinc-finger, chromosomal protein, methylation, three-leaved beta-propeller, transcription, p53
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q9Y468; Cytoplasm: Q5U0E4
• Total number of polymer chains: 5
• Total formula weight: 119997.16

Authors

Roy, S.,West, L.E.,Weiner, K.L.,Hayashi, R.,Shi, X.,Appella, E.,Gozani, O.,Kutateladze, T. (deposition date: 2010-09-02, release date: 2010-09-22, Last modification date: 2023-09-06)

• Primary citation: West, L.E.,Roy, S.,Lachmi-Weiner, K.,Hayashi, R.,Shi, X.,Appella, E.,Kutateladze, T.G.,Gozani, O.; The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression.; J.Biol.Chem., 285:37725-37732, 2010; PubMed: 20870725; DOI: 10.1074/jbc.M110.139527

Experimental method

X-RAY DIFFRACTION (2.5005 Å)