3OQ5

Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1

3OQ5 の概要

• エントリーDOI: 10.2210/pdb3oq5/pdb
• 分子名称: Lethal(3)malignant brain tumor-like protein, Cellular tumor antigen p53 (3 entities in total)
• 機能のキーワード: l(3)mbt-like protein, protein lysine methyltransferase; malignant brain tumor, chromatin regulator, dna-binding, metal-binding, nucleus, repressor, transcription regulation, zinc-finger, chromosomal protein, methylation, three-leaved beta-propeller, transcription, p53
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q9Y468; Cytoplasm: Q5U0E4
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 119997.16

構造登録者

Roy, S.,West, L.E.,Weiner, K.L.,Hayashi, R.,Shi, X.,Appella, E.,Gozani, O.,Kutateladze, T. (登録日: 2010-09-02, 公開日: 2010-09-22, 最終更新日: 2023-09-06)

• 主引用文献: West, L.E.,Roy, S.,Lachmi-Weiner, K.,Hayashi, R.,Shi, X.,Appella, E.,Kutateladze, T.G.,Gozani, O.; The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression.; J.Biol.Chem., 285:37725-37732, 2010; PubMed: 20870725; DOI: 10.1074/jbc.M110.139527

実験手法

X-RAY DIFFRACTION (2.5005 Å)