3OP8

Crystal structure of the domain V from beta2-glycoprotein I

Summary for 3OP8

Entry DOI	10.2210/pdb3op8/pdb
Related	1C1Z 1QUB
Descriptor	Beta-2-glycoprotein 1, SULFATE ION (3 entities in total)
Functional Keywords	sushi, antiphospholipid syndrome, anionic phospholipids binding, lipoprotein receptors binding, blood plasma, protein binding
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02749
Total number of polymer chains	2
Total formula weight	19548.51
Authors	Kolyada, A.,Lee, C.-J.,De Biasio, A.,Beglova, N. (deposition date: 2010-08-31, release date: 2011-01-05, Last modification date: 2011-07-13)
Primary citation	Kolyada, A.,Lee, C.J.,De Biasio, A.,Beglova, N. A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome. Plos One, 5:e15345-e15345, 2010 Cited by PubMed Abstract: β2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of β2GPI generated by anti-β2GPI antibodies is pathologically important, in contrast to monomeric β2GPI which is abundant in plasma. PubMed: 21179511 DOI: 10.1371/journal.pone.0015345 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation