3OOM

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507

Summary for 3OOM

• Entry DOI: 10.2210/pdb3oom/pdb
• Related: 3MTF
• Descriptor: Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ... (5 entities in total)
• Functional Keywords: protein kinase, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 1
• Total formula weight: 35994.98

Authors

Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-31, release date: 2010-10-13, Last modification date: 2023-11-01)

• Primary citation: Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.; Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)