3OKJ
Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition
Summary for 3OKJ
Entry DOI | 10.2210/pdb3okj/pdb |
Related | 1G65 1J2Q 1RYP 3D29 |
Related PRD ID | PRD_001051 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | ubiquitin, protease, inhibitor, central antiparallel beta-sheet flanked by helices, turnover of ubiquitinated substrates, nucleus, cytosol, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 705317.56 |
Authors | Groll, M.,Poynor, M.,Gallastegui, P.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R. (deposition date: 2010-08-25, release date: 2011-06-08, Last modification date: 2023-09-06) |
Primary citation | Grawert, M.A.,Gallastegui, N.,Stein, M.,Schmidt, B.,Kloetzel, P.M.,Huber, R.,Groll, M. Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition Angew.Chem.Int.Ed.Engl., 50:542-544, 2011 Cited by PubMed: 21154547DOI: 10.1002/anie.201005488 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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