3OIM

Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate

3OIM の概要

関連するPDBエントリー3OIK 3OIL 3OKU 3OKV
分子名称Carbonic anhydrase 2, ZINC ION, (14beta,17alpha)-2-ethyl-17-hydroxyestra-1(10),2,4-trien-3-yl sulfamate, ... (6 entities in total)
機能のキーワード2-ethylestrone, estradiol, sulfamate, mixed alpha-beta, carbon dioxide/bicarbonate conversion, lyase
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm P00918
ポリマー鎖数1
分子量合計29904.21
構造登録者
Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R. (登録日: 2010-08-19, 公開日: 2011-07-06, 最終更新日: 2011-07-13)
主引用文献
Sippel, K.H.,Stander, B.A.,Robbins, A.H.,Tu, C.K.,Agbandje-McKenna, M.,Silverman, D.N.,Joubert, A.M.,McKenna, R.
Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds
LETT.DRUG DES.DISCOVERY, 8:-, 2011
実験手法
X-RAY DIFFRACTION (1.45 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.16860.4%0.4%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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