3OEZ
crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain complexed with imatinib
Summary for 3OEZ
Entry DOI | 10.2210/pdb3oez/pdb |
Related | 2OIQ 3OF0 |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ACETATE ION, ... (5 entities in total) |
Functional Keywords | c-src l317i mutant, tyrosine kinase, imatinib, transferase |
Biological source | Gallus gallus (bantam,chickens) |
Cellular location | Cell membrane (By similarity): P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66591.63 |
Authors | Boubeva, R.,Pernot, L.,Perozzo, R.,Scapozza, L. (deposition date: 2010-08-13, release date: 2011-08-17, Last modification date: 2023-09-06) |
Primary citation | Boubeva, R.,Pernot, L.,Cristiani, A.,Moretti, L.,Berteotti, A.,Perozzo, R.,Gervasio, F.,Scapozza, L. a single amino-acid dictates the dynamics of the switch between active and inactive C-Src conformation To be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report