3ODQ
Structure of a Crystal Form of Human Methemoglobin Indicative of Fiber Formation
Summary for 3ODQ
| Entry DOI | 10.2210/pdb3odq/pdb |
| Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
| Functional Keywords | structural genomics, psi-2, protein structure initiative, center for high-throughput structural biology, chtsb, oxygen transport, oxygen binding, heme group, red blood cells |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 64547.05 |
| Authors | Larson, S.B.,Day, J.S.,Nguyen, C.,Cudney, R.,Mcpherson, A.,Center for High-Throughput Structural Biology (CHTSB) (deposition date: 2010-08-11, release date: 2010-12-01, Last modification date: 2023-09-06) |
| Primary citation | Larson, S.B.,Day, J.S.,Nguyen, C.,Cudney, R.,McPherson, A. Structure of a crystal form of human methemoglobin indicative of fiber formation. Acta Crystallogr.,Sect.D, 66:1316-1322, 2010 Cited by PubMed Abstract: Human methemoglobin was crystallized in a unique unit cell and its structure was solved by molecular replacement. The hexagonal unit cell has unit-cell parameters a = b = 54.6, c = 677.4 Å, with symmetry consistent with space group P6₁22. The unit cell has the second highest aspect ratio of all unit cells contained in the PDB. The 12 molecules in the unit cell describe a right-handed helical filament having no polarity, which is different from the filament composed of HbS fibers, which is the only other well characterized fiber of human hemoglobin. The filaments reported here can be related to canonical sickle-cell hemoglobin filaments and to an alternative sickle-cell filament deduced from fiber diffraction by slight modifications of intermolecular contacts. PubMed: 21123872DOI: 10.1107/S0907444910040370 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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