3OB1

Crystal structure of c-Cbl TKB domain in complex with double phosphorylated Spry2 peptide

3OB1 の概要

• エントリーDOI: 10.2210/pdb3ob1/pdb
• 関連するPDBエントリー: 3OB2
• 分子名称: 12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL (3 entities in total)
• 機能のキーワード: protein-peptide complex, double phosphorylation, complex, e3 ubiquitin ligase, spry2, phosphorylation, ligase-signaling protein complex, ligase/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton : O43597; Cytoplasm: P22681
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39747.50

構造登録者

Sun, Q.,Sivaraman, J. (登録日: 2010-08-06, 公開日: 2010-08-18, 最終更新日: 2023-12-06)

• 主引用文献: Sun, Q.,Jackson, R.A.,Ng, C.,Guy, G.R.,Sivaraman, J.; Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain; Plos One, 5:e12819-e12819, 2010; PubMed: 20877636; DOI: 10.1371/journal.pone.0012819

実験手法

X-RAY DIFFRACTION (2.2 Å)