3OAD
Design and optimization of new piperidines as renin inhibitors
Summary for 3OAD
Entry DOI | 10.2210/pdb3oad/pdb |
Related | 3OAG 3OL9 |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,4R)-N-[2-chloro-5-(2-methoxyethyl)benzyl]-N-cyclopropyl-4-{6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl}-4-hydroxypiperidine-3-carboxamide, ... (5 entities in total) |
Functional Keywords | protease, blood, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00797 P00797 |
Total number of polymer chains | 4 |
Total formula weight | 77079.50 |
Authors | Prade, L. (deposition date: 2010-08-05, release date: 2010-11-03, Last modification date: 2020-07-29) |
Primary citation | Corminboeuf, O.,Bezencon, O.,Grisostomi, C.,Remen, L.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Hess, P.,Strickner, P.,Fischli, W.,Steiner, B.,Treiber, A. Design and optimization of new piperidines as renin inhibitors. Bioorg.Med.Chem.Lett., 20:6286-6290, 2010 Cited by PubMed: 20843686DOI: 10.1016/j.bmcl.2010.08.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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