3O96
Crystal Structure of Human AKT1 with an Allosteric Inhibitor
Summary for 3O96
Entry DOI | 10.2210/pdb3o96/pdb |
Descriptor | RAC-alpha serine/threonine-protein kinase, 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one (3 entities in total) |
Functional Keywords | pleckstrin homology, protein kinase, allosteric inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P31749 |
Total number of polymer chains | 1 |
Total formula weight | 52414.73 |
Authors | Voegtli, W.C.,Wu, W.-I.,Lord-Ondash, H.A.,Dizon, F.P.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-08-03, release date: 2010-10-13, Last modification date: 2024-10-16) |
Primary citation | Wu, W.I.,Voegtli, W.C.,Sturgis, H.L.,Dizon, F.P.,Vigers, G.P.,Brandhuber, B.J. Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition. Plos One, 5:12913-12913, 2010 Cited by PubMed: 20886116DOI: 10.1371/journal.pone.0012913 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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