3O96

Crystal Structure of Human AKT1 with an Allosteric Inhibitor

3O96 の概要

• エントリーDOI: 10.2210/pdb3o96/pdb
• 分子名称: RAC-alpha serine/threonine-protein kinase, 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one (3 entities in total)
• 機能のキーワード: pleckstrin homology, protein kinase, allosteric inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P31749
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52414.73

構造登録者

Voegtli, W.C.,Wu, W.-I.,Lord-Ondash, H.A.,Dizon, F.P.,Vigers, G.P.A.,Brandhuber, B.J. (登録日: 2010-08-03, 公開日: 2010-10-13, 最終更新日: 2023-09-06)

• 主引用文献: Wu, W.I.,Voegtli, W.C.,Sturgis, H.L.,Dizon, F.P.,Vigers, G.P.,Brandhuber, B.J.; Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.; Plos One, 5:12913-12913, 2010; PubMed: 20886116; DOI: 10.1371/journal.pone.0012913

実験手法

X-RAY DIFFRACTION (2.7 Å)