3O6O

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021

Summary for 3O6O

• Entry DOI: 10.2210/pdb3o6o/pdb
• Descriptor: Heat shock protein 83, 6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-9H-purin-2-amine, PENTAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: trypanosoma, african sleeping sickness, heat shock protein, structural genomics, structural genomics consortium, sgc, chaperone
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 2
• Total formula weight: 48989.90

Authors

Wernimont, A.K.,Hutchinson, A.,Sullivan, H.,Weadge, J.,Li, Y.,Kozieradzki, I.,Cossar, D.,Bochkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Wyatt, P.,Fairlamb, A.H.,Ferguson, M.A.J.,Thompson, S.,MacKenzie, C.,Hui, R.,Pizarro, J.C.,Hills, T.,Structural Genomics Consortium (SGC) (deposition date: 2010-07-29, release date: 2010-08-18, Last modification date: 2022-10-05)

• Primary citation: Pizarro, J.C.,Hills, T.,Senisterra, G.,Wernimont, A.K.,Mackenzie, C.,Norcross, N.R.,Ferguson, M.A.,Wyatt, P.G.,Gilbert, I.H.,Hui, R.; Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.; PLoS Negl Trop Dis, 7:e2492-e2492, 2013; PubMed: 24147171; DOI: 10.1371/journal.pntd.0002492

Experimental method

X-RAY DIFFRACTION (2 Å)