3O5X
Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
Replaces: 3JRLSummary for 3O5X
Entry DOI | 10.2210/pdb3o5x/pdb |
Related | 3JRL |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid (3 entities in total) |
Functional Keywords | shp2-iib-08 complex, inhibitor, binding affinity, binding selectivity, receptor, hydrolase, dephosphorylation |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 32835.30 |
Authors | Zhang, Z.-Y.,Zhang, X.,He, Y.,Liu, S.,Yu, Z.,Jiang, Z.,Yang, Z.,Dong, Y.,Nabinger, S.C.,Wu, L.,Gunawan, A.M.,Wang, L.,Chan, R.J. (deposition date: 2010-07-28, release date: 2010-08-11, Last modification date: 2023-09-06) |
Primary citation | Zhang, X.,He, Y.,Liu, S.,Yu, Z.,Jiang, Z.X.,Yang, Z.,Dong, Y.,Nabinger, S.C.,Wu, L.,Gunawan, A.M.,Wang, L.,Chan, R.J.,Zhang, Z.Y. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J.Med.Chem., 53:2482-2493, 2010 Cited by PubMed: 20170098DOI: 10.1021/jm901645u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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