3O5X
Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor
Replaces: 3JRLEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 276 | 32277.7 | 1 | UniProt (Q06124) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 2C, PTP-2C, Protein-tyrosine phosphatase 1D, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2 |
2 | A | 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid | non-polymer | 557.6 | 1 | Chemie (JZG) | |||
3 | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A: 262 - 528 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Met 261 | - | expression tag |
- | Gln 408 | variant |
- | Ala 409 | variant |
- | Leu 410 | variant |
- | Leu 411 | variant |
Leu 529 | - | expression tag |
Glu 530 | - | expression tag |
His 531 | - | expression tag |
His 532 | - | expression tag |
His 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32277.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 557.6 | |
All* | Total formula weight | 32835.3 |