3O3H

T. maritima RNase H2 D107N in complex with nucleic acid substrate and manganese ions

Summary for 3O3H

• Entry DOI: 10.2210/pdb3o3h/pdb
• Related: 2etj 3O3F 3O3G
• Descriptor: Ribonuclease HII, DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), DNA/RNA (5'-D(*GP*AP*CP*AP*C)-R(P*C)-D(P*TP*GP*AP*TP*TP*C)-3'), ... (5 entities in total)
• Functional Keywords: rnase h fold, nuclease, hydrolase-dna-rna hybrid complex, hydrolase/dna-rna hybrid
• Biological source: Thermotoga maritima
• Cellular location: Cytoplasm (Potential): Q9X017
• Total number of polymer chains: 3
• Total formula weight: 32188.27

Authors

Rychlik, M.P.,Chon, H.,Cerritelli, S.M.,Klimek, P.,Crouch, R.J.,Nowotny, M. (deposition date: 2010-07-24, release date: 2010-12-08, Last modification date: 2024-02-21)

• Primary citation: Rychlik, M.P.,Chon, H.,Cerritelli, S.M.,Klimek, P.,Crouch, R.J.,Nowotny, M.; Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage.; Mol.Cell, 40:658-670, 2010; PubMed: 21095591; DOI: 10.1016/j.molcel.2010.11.001

Experimental method

X-RAY DIFFRACTION (2.8 Å)